Draaisma, Douwe, ref 1, ref 2n 24Pous prescriptions: The pharmacist, Philip J. Duet Jr., recorded dispensing the drugs on the perpetual controlled drug inventory. In an interview with state investigators on October 25, 2005, he initially said he could not recall having been asked for any large quantities of morphine. However, once he was shown copies of the logs, he confirmed that he had filled the prescriptions. He said he thought two young female doctors came for the drugs, and the large amounts could have been to travel with the patients. But Burkitt was beginning to revise Cleaves hypothesis. Now Burkitts working assumption, as he explained in theJNCI, was that any dietary factors responsible for benign conditions such as appendicitis or diverticulitis were likely to be responsible as well for related malignant conditionsin particular, colon and rectal cancer. Burkitts research had led him to Thomas Allinson, who in the 1880s argued that white flour caused constipation, hemorrhoids, and other ills of modern societies. It also led him to a 1920 article by the Bristol University surgeon Arthur Rendle Short, documenting a dramatic increase in the incidence of appendicitis that Rendle Short also blamed on white flour and the lack of fiber in modern diets. Burkitt believed he could draw a direct line of causation from the absence of fiber in refined carbohydrates to constipation, hemorrhoids, appendicitis, diverticulitis, polyps, and finally malignant colon and rectal cancer.